Contemporary functional neuroanatomy and pathophysiology of dystonia

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منابع مشابه

[Pathophysiology of dystonia].

Dystonia is a diverse movement disorder characterized by involuntary muscle co-contraction of the agonist and antagonist, which may cause twisting and repetitive movements or abnormal posture. Dystonia is the least understood movement disorder associated with the basal ganglia dysfunction. While dysfunction of cortico-striatal-thalamo-cortical motor circuits is likely to play a fundamental role...

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[Pathophysiology in dystonia: functional anatomy of basal ganglia].

Clinical manifestation of dystonia features involuntary muscle contraction or spasm resulting in postural and movement disorders. Depending on the distribution and spreading pattern of dystonia, four patterns have been described, including focal, segmental, multifocal and generalized dystonia. Dystonia can be seen as one of additional clinical features in a more severe neurologic condition. Mos...

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The pathophysiology of primary dystonia.

Co-contraction and overflow of EMG activity of inappropriate muscles are typical features of all dystonic movements whether voluntary or involuntary. Voluntary movements are slow and more variable than normal, and there is particular difficulty switching between component movements of a complex task. Reduced spinal cord and brainstem inhibition is common to many reflex studies (long-latency ref...

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Dystonia Pathophysiology: A Critical Review

During the past years, dramatic progress have been achieved in our knowledge of the pathophysiology of dystonia on the basis of imaging and electrophysiological data collected in human patients. Converging arguments now support the role of combined corticostriatal and cerebellar dysfunctions in the genesis of this movement disorder (1). Several excellent reviews have been recently proposed on t...

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ژورنال

عنوان ژورنال: Journal of Neural Transmission

سال: 2021

ISSN: 0300-9564,1435-1463

DOI: 10.1007/s00702-021-02299-y